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    NFkB p65 Mouse mAb
    EM1111
    規格: 價格:
    50μL ¥1280.00
    100μL ¥1980.00

    Overview 文獻

    Product name: NFkB p65 Mouse mAb
    Reactivity: Human, Rat, Mouse
    Alternative Names: NFKB3, p65, RELA, Transcription factor p65
    Source: Mouse
    Dilutions: WB 1:500-2,000 IP 1:200 IF 1:100-200 IHC 1:200-500
    Immunogen: Recombinant Protein
    Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
    Clonality: Monoclonal
    Isotype: IgG1
    Concentration: 1mg/mL
    Observed Band: 65kDa
    GeneID: 5970
    Human Swiss-Prot No: Q04206
    Cellular localization: Cytoplasm,?Nucleus
    Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
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